Ai KOHATA,  PhD

Assistant Professor, School of Life Science and Engineering, Tokyo Institute of Technology
E-mail:aikohata [at] bio.titech.ac.jp
ORCiD:0000-0003-2019-559X
Researcher Number:30851852researchmap


Field of Study:Chemical Biology, Supermolecular Chemistry, Fluoroorganic Chemistry

Education

2019-2022 Ph.D. (Engineering), The University of Tokyo
Thesis: Molecular Glues for Nucleic Acids in Biomedical Applications
Supervisor: Prof. Takuzo Aida

2017-2019 M.S., The University of Tokyo
2013-2017 B.S., The University of Tokyo, Supramolecular chemistry and chemical biology,
Advisor: Prof. Takuzo Aida


Professional Appointments

2023/07–Present        Assistant Professor, School of Life Science and Engineering, Tokyo Institute of Technology
2022/04–2023/06 Project assistant professor, The University of Tokyo
2019/04–2022/03 Japan Society for the Promotion of Science (JSPS) research fellow 


Publications (Original Paper)

4. Synthesis of Short Peptides with Perfluoroalkyl Side Chains and Evaluation of Their Cellular Uptake Efficiency

Koji Kadota, Toshiki Mikami, Ai Kohata, Jumpei Morimoto, Shinsuke Sando, Kohsuke Aikawa,* and Takashi Okazoe

Chembiochem. 2023, e202300374.

 

3. Reconstitution of Microtubule into GTP-Responsive Nanocapsules

Noriyuki Uchida, Ai Kohata, Kou Okuro, Annalisa Cardellini, Chiara Lionello, Eric A. Zizzi, Marco A. Deriu, Giovanni M. Pavan, Michio Tomishige, Takaaki Hikima, Takuzo Aida*

Nat. Commun. 2022, 13, 5424.

 

2. Photoreactive Molecular Glue for Enhancing the Efficacy of DNA Aptamers by Temporary-to-Permanent Conjugation with Target Proteins

Ai Kohata, Ryosuke Ueki, Kou Okuro,* P. K. Hashim, Shinsuke Sando, and Takuzo Aida*

J. Am. Chem. Soc. 2021, 143, 13937–13943.

 

1. Transferrin-Appended Nanocaplet for siRNA Delivery into Deep Tissues

Ai Kohata, P. K. Hashim, Kou Okuro,* and Takuzo Aida*

J. Am. Chem. Soc. 2019, 141, 2862–2866.  (selected as “Front Cover”)

 

Book

第6章 第8節 ペルフルオロ構造を利用したペプチドや核酸の細胞内送達技術. 『新規モダリティ医薬品のための新しいDDS 技術と製剤化』

岡添隆, 相川光介, 木幡愛

(株)技術情報協会, 東京(2023年1月31日), p 325–332.

 

Patent

(1)「フルオロアルケン共重合体」

          発明者: 柏木王明、岡添隆、杉山徳英、秋山みどり、木幡愛、増田潤季、奥田瑞来

          出願人: 国立大学法人東京大学、AGC 株式会社

          特願 2022-175052, 2022.10.31

(2)「コンジュゲート用細胞膜透過性ペプチド」

          発明者: 柏木王明、岡添隆、相川光介、山東信介、森本淳平、木幡愛、門田晃司

          出願人: 国立大学法人東京大学、AGC 株式会社

          特願 2022-170448, 2022.10.25

(3)「トランスフェクション用核酸」

          発明者: 岡添隆、相川光介、岡本晃充、森廣邦彦、木幡愛

          出願人: 国立大学法人東京大学、AGC 株式会社

          特願 2023-033984, 2023.03.06

(4)「含フッ素化合物」

          発明者: 太田有羽、岡添隆、相田卓三、ゴスワミ・アビール、木幡愛

          出願人: 国立大学法人東京大学、国立研究開発法人理化学研究所、AGC 株式会社

          特願 2024-072312, 2024.04.26


Awards

2023/10 Excellent oral presentation award, The 46th Fluorine Conference o Japan

2022/11 ISNAC outstanding poster award in 2022, the 49th International Symposium on
Nucleic Acid Chemistry (ISNAC)
2022/09 The L'Oréal-UNESCO for women in science Japan fellowships 2022
2022/03 Chemical Society of Japan (CSJ) student presentation award, the 102th CSJ annual meeting
2022/03 Dean’s award, graduate school of engineering, the University of Tokyo
2022/03 Best team presentation award, JSPS 13th HOPE meeting
2021 Funakoshi Ryuta award, Funakoshi Co., Ltd.
2020 First Prize, Idea pitch contest, Johnson and Johnson K. K.
2019/03 Best presentation award, 139th annual meeting of the pharmaceutical society of Japan
2019/03 Dean’s award, graduate school of engineering, the University of Tokyo
2018/12 The 12th SPSJ International Polymer Conference, IPC2018 Young Scientist Poster Award
2016 Best presentation award, OIST science challenge workshop 2016 

Grants-in-Aid for Scientific Research

2023/04–2025/03 Grant-in-Aid for Early-Career ScientistsRepresentative
2019/04–2022/03 Japan Society for the Promotion of Science (JSPS) research fellow (Representative)


Research Grants

2023/04–2025/03 The Kao Foundation for Arts and Sciences, The 2nd Kao Crescent Award