Hiroka SUGAI, PhD

Research Center for Autonomous Systems Materialogy (ASMat), Institute of Innovative Research, Tokyo Institute of Technology; JST PRESTO Researcher

E-mail:sugai.h.aa [a] m.titech.ac.jp
ORCiD:0000-0002-5957-0011
Publons:AAP-9890-2000
Researcher Number10905566researchmap

Field of Study:Biomacromolecular Chemistry, Supramolecular Chemistry, Analytical Chemistry  

Education

2015/04–2018/03 Ph.D.   Tohoku University
Department of Chemistry, Graduate School of Science, Tohoku University
2013/04–2015/03 M.Sc.   Tohoku University
Department of Chemistry, Graduate School of Science, Tohoku University
2009/04–2013/03 B.Sc.    Tohoku University
Department of Chemistry, Faculty School of Science, Tohoku University

Professional Appointments

2024Present Specially Appointed Assistant Professor, Institute of Innovative Research, Tokyo Institute of Technology
2022–2024 Specially Appointed Assistant Professor, International Research Frontiers Initiative, Tokyo Institute of Technology
2022–Present JST PRESTO Researcher
2021–2022 Assistant Professor, Faculty of Pure and Applied Sciences, University of Tsukuba
2018–2021 Postdoctoral Researcher,  Department of Life Science and Biotechnology,
National Institute of Advanced Industrial Science and Technology
2016–2018 JSPS Young Researcher 

Publications (Original Paper)

Transient Formation of Multi-phase Droplets Caused by the Addition of a Folded Protein into Complex Coacervates with an Oppositely Charged Surface Relative to the Protein
Nanako Sakakibara, Tomoto Ura, Tsutomu Mikawa, Hiroka Sugai,* and Kentaro Shiraki*
Soft Matter, 2023, 19, 4642–4650. (Selected as a back cover)

Dense and Acidic Organelle-Targeted Visualization in Living Cells: Application of Viscosity-Responsive Fluorescence Utilizing Restricted Access to Minimum Energy Conical Intersection
Junya Adachi, Haruka Oda, Toshiaki Fukushima,* Beni Lestari, Hiroshi Kimura, Hiroka Sugai, Kentaro Shiraki, Rei Hamaguchi, Kohei Sato, and Kazushi Kinbara*
Analytical Chemistry, 2023, 95, 5196–5204.

Phase-Separation Propensity of Non-ionic Amino Acids in Peptide-Based Complex Coacervation Systems
Yuto Akahoshi, Hiroka Sugai, Masahiro Mimura, Yoichi Shinkai, Ryoji Kurita, Kentaro Shiraki, and Shunsuke Tomita*
Biomacromolecules, 2023, 24, 704–713. (Selected as a supplementary cover)

Damage-Free Evaluation of Cultured Cells Based on Multivariate Analysis with a Single-Polymer Probe
Hiroka Sugai,* Shunsuke Tomita, Sayaka Ishihara, Kentaro Shiraki, and Ryoji Kurita*
Chemical Communications, 2022, 58, 1108311086. (Selected as an inside front cover)

Uncharged Components of Single-Stranded DNA Modulated Liquid-Liquid Phase Separation with Cationic Linker Histone H1
Masahiro Mimura, Shunsuke Tomita,* Hiroka Sugai, Yoichi Shinkai, Sayaka Ishihara, and Ryoji Kurita*
Frontiers in Cell and Developmental Biology, 2021, 9, 710729. (Special Issue “Biological Phase Separation”)

A Biomimetic Sensor Array Based on a Single Fluorescent Block-Copolymer for the Pattern Recognition of Proteins
Shunsuke Tomita,* Hiroka Sugai, Sayaka Ishihara, Takuya Hosokai, and Ryoji Kurita*
Chemistry Letters, 2020, 49, 1447–1451. (Selected as an editor's choice and an inside cover)

Microfluidic Sensing System with a Multichannel Surface Plasmon Resonance Chip: Damage-Free Characterization of Cells by Pattern Recognition
Hiroka Sugai, Shunsuke Tomita,* Sayaka Ishihara, Kyoko Yoshioka, and Ryoji Kurita*
Analytical Chemistry, 2020, 92, 14939–14946.

A Multichannel Pattern-Recognition-Based Protein Sensor with a Fluorophore-Conjugated Single-Stranded DNA Set
Mari Okada, Hiroka Sugai, Shunsuke Tomita,* and Ryoji Kurita*
Sensors, 2020, 20, 5110. (Special Issue “Nanosensors for Biomedical Application”)

Optical Fingerprints of Proteases and Their Inhibited Complexes Provided by Differential Cross-Reactivity of Fluorophore-Labeled Single-Stranded DNA
Shunsuke Tomita,* Hiroka Sugai, Masahiro Mimura, Sayaka Ishihara, Kentaro Shiraki, and Ryoji Kurita*
ACS Applied Materials & Interfaces, 2019, 11, 47428–47436.

One-Component Array Based on a Dansyl-Modified Polylysine: Generation of Differential Fluorescent Signatures for the Discrimination of Human Cells
Hiroka Sugai, Shunsuke Tomita,* Sayaka Ishihara, and Ryoji Kurita*
ACS Sensors, 2019, 4, 827–831.

Fingerprint-Based Protein Identification in Cell Culture Medium Using Environment-Sensitive Turn-On Fluorescent Polymer
Hiroka Sugai, Shunsuke Tomita,* Sayaka Ishihara, and Ryoji Kurita*
Sensors and Materials, 2019, 31, 1–11. (Special Issue "Micro/Nano Sensing Platforms Exploring Biomedical Innovation")

Peptide Ribonucleic Acid (PRNA)-Arginine Hybrids. Effects of Arginine Residues Alternatingly Introduced to PRNA Backbone on Aggregation, Cellular Uptake, and Cytotoxicity
Hiroka Sugai, Ikuhiko Nakase, Seiji Sakamoto, Akihiro Nishio, Masahito Inagaki, Masaki Nishijima, Asako Yamayoshi, Yasuyuki Araki, Satoru Ishibashi, Takanori Yokota, Yoshihisa Inoue, and Takehiko Wada*
Chemistry Letters, 2018, 47, 381384.

Module Strategy for Peptide Ribonucleic Acid (PRNA)-DNA and PRNA-Peptide Nucleic Acid (PNA)-DNA Chimeras. Synthesis and Interaction of Chimeras with DNA and RNA
Ryohei Uematsu, Masahito Inagaki, Mitsuo Asai, Hiroka Sugai, Yoshiki Maeda, Akira Nagami, Hirofumi Sato, Seiji Sakamoto, Yasuyuki Araki, Masaki Nishijima, Yoshihisa Inoue, and Takehiko Wada*
Chemistry Letters, 2016, 45, 350–352.

Reviews and Commentaries

Pattern-Recognition-Based Sensor Arrays for Cell Characterization: From Materials and Data Analyses to Biomedical Applications
Hiroka Sugai, Shunsuke Tomita,* and Ryoji Kurita*

Analytical Sciences, 2020, 36, 923–934. (Selected as a hot article)

Reviews and Commentaries in Japanese

オンチップセンシング技術 ーマイクロバイオセンシングー
栗田 僚二, 菅井 祥加, 冨田 峻介
電気学会誌, 2024, 144, 205208.

細胞培養液の特徴パターンを認識するchemical tongue
菅井 祥加, 冨田 峻介, 栗田 僚二
細胞, 2023, 55, 347–351.

特徴パターンの認識
菅井 祥加, 冨田 峻介,
現在化学増刊 46 相分離生物学の全貌, 白木 賢太郎 編, 東京化学同人, 2020, 第VI部 70章, 343–348.

分子アレイデバイスと多変量解析による生体試料評価
冨田 峻介, 菅井 祥加, 南木 創, 栗田 僚二
電気化学, 2020, 88, 262–271.

生体試料の特徴情報を出力する交差反応性ポリマーアレイを利用したバイオメトリクス
菅井 祥加, 冨田 峻介, 栗田 僚二
ケミカルエンジニヤリング, 2018, 63, 842–849.